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FSB

Names

[ CAS No. ]:
760988-03-2

[ Name ]:
FSB

[Synonym ]:
Benzoic acid, 3,3'-[(2-fluoro-1,4-phenylene)di(E)-2,1-ethenediyl]bis[6-hydroxy-
3,3'-[(2-Fluoro-1,4-phenylene)di(E)-2,1-ethenediyl]bis(6-hydroxybenzoic acid)
1-Fluoro-2,5-bis[(E)-3-carboxy-4-hydroxystyryl]benzene solution
FSB staining solution
3,3'-[(2-Fluoro-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis[6-hydroxybenzoic acid] solution
3,3'-[(2-fluorobenzene-1,4-diyl)di(E)ethene-2,1-diyl]bis(6-hydroxybenzoic acid)

Biological Activity

[Description]:

FSB is a fluorescent dye that can be used to detect filamentous tau and to label human amyloid lesions with high sensitivity and specificity (excitation: 390 nm, emission: 520 nm)[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Velasco A, et al. Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans,trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]. FEBS Lett. 2008 Mar 19;582(6):901-6.

[2]. Sato K, et al. Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques. Eur J Med Chem. 2004 Jul;39(7):573-8.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
663.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H17FO6

[ Molecular Weight ]:
420.387

[ Flash Point ]:
355.0±31.5 °C

[ Exact Mass ]:
420.100922

[ LogP ]:
7.66

[ Appearance of Characters ]:
solid

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.783

[ Storage condition ]:
Store at -20°C

[ Water Solubility ]:
Soluble in DMSO

Related Compounds