4-(4-Isothiocyanatophenylazo)-N,N-dimethylaniline

Names

[ Name ]:
4-(4-Isothiocyanatophenylazo)-N,N-dimethylaniline

[Synonym ]:
4-((4-Isothiocyanatophenyl)azo)-N,N-dimethylaniline
4-[(4-isothiocyanatophenyl)diazenyl]-N,N-dimethylaniline
Benzenamine, 4-[(E)-2-(4-isothiocyanatophenyl)diazenyl]-N,N-dimethyl-
EINECS 231-521-3
MFCD00004812
4-[(E)-(4-Isothiocyanatophenyl)diazenyl]-N,N-dimethylaniline

Biological Activity

[Description]:

4-(N,N-Dimethylamino)azobenzene-4'-isothiocyanate is a chromophoric, hydrophobic reagent for probing membrane-buried segments of intrinsic proteins[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Kempf C, et al. 4-N-N-dimethylamino-azobenzene-4'-isothiocyanate: a chromophoric, hydrophobic reagent for probing membrane-buried segments of intrinsic proteins. FEBS Lett. 1981 Feb 23;124(2):225-8.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
466.2±30.0 °C at 760 mmHg

[ Melting Point ]:
167-171 °C(lit.)

[ Molecular Formula ]:
C₁₅H₁₄N₄S

[ Molecular Weight ]:
282.363

[ Flash Point ]:
235.7±24.6 °C

[ Exact Mass ]:
282.093903

[ PSA ]:
72.41000

[ LogP ]:
5.95

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.613

[ Water Solubility ]:
dioxane: 20 mg/mL, clear, red

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H317-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
42

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NX9125000

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

A new isotype sequence (V kappa 27) of the variable region of kappa-light chains from a mouse hybridoma-derived anti-(streptococcal group A polysaccharide) antibody containing an additional cysteine residue. Application of the dimethylaminoazobenzene isothiocyanate technique for the isolation of peptides.

Biochem. J. 211(1) , 173-80, (1983)

The first complete sequence of the variable region of a kappa-light chain (V kappa) from a mouse anti-(streptococcal group A polysaccharide) antibody (immunoglobulin 7S34.1) is reported. Immunoglobuli...

Peptide maps at picomolar levels obtained by reversed-phase high-performance liquid chromatography and pre-column derivatization with phenyl isothiocyanate. Microsequencing of Phenylthiocarbamyl Peptides.

J. Chromatogr. A. 548(1-2) , 303-10, (1991)

A new reversed-phase high-performance liquid chromatography approach to the production of analytical peptide maps by pre-column derivatization using phenylisothiocyanate is described. Tryptic peptide ...

Evidence for the formation of a novel glutathione conjugate in the metabolism of an aromatic amine derivative.

Drug Metab. Dispos. 12(4) , 523-4, (1984)