8-Hydroxy-DPAT hydrobromide

Names

[ Name ]:
8-Hydroxy-DPAT hydrobromide

[Synonym ]:
8-OH-DPAT HRr
rac-8-Hydroxy-2-dipropylaMinotetralin HydrobroMide
Serotonin agonist DPAT
8-OH-DPAT hydrobromide
8-hydroxydipropyl-aminotetralin
8-OH-DPAT HBr

Biological Activity

[Description]:

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-Hydroxy-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT1A Receptor:8.19 (pIC50)

[In Vitro]

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) has no effect on 5-HT1B binding at concentrations lower than 100 nM[1].

[In Vivo]

8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide; 32, 56, 80, 100 mg/kg; intramuscularly; 15 min prior to the testing session) of the highest dose significantly interferes with sustained attention and reinforcer efficacy (progressive ratio; PR) performance in the 3,4-methylenedioxymethamphetamine (MDMA)-exposed but not control animals[1].

[References]

[1]. D N Middlemiss, et al. 8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT₁ recognition site. Eur J Pharmacol. 1983 May 20;90(1):151-3.

[2]. Michael A Taffe, et al. Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge. Neuropsychopharmacology. 2002 Dec;27(6):993-1005.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₆BrNO

[ Molecular Weight ]:
328.28800

[ Exact Mass ]:
327.12000

[ PSA ]:
23.47000

[ LogP ]:
4.32960

[ Storage condition ]:
2-8°C

Safety Information

[ HS Code ]:
2922299090

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%