Clathrin-IN-4

Names

[ CAS No. ]:
762242-59-1

[ Name ]:
Clathrin-IN-4

Biological Activity

[Description]:

Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Cytoskeleton >> Dynamin

[References]

[1]. Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H18Br2N2O

[ Molecular Weight ]:
426.15

Related Compounds