ORM-10962

Names

[ Name ]:
ORM-10962

Biological Activity

[Description]:

ORM-10962 is a potent, highly selective sodium-calcium exchanger (NCX) inhibitor, with IC50 values of 67 and 55 nM for the reverse and forward mode inhibition, respectively[1][2].

[Related Catalog]:

Research Areas >> Others

[Target]

NCX[1][2].

[References]

[1]. Kohajda Z, et al. The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments. PLoS One. 2016 Nov 10;11(11):e0166041.

[2]. Oravecz K, et al. Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes. Eur J Pharmacol. 2018 Jan 5;818:278-286.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₂₉N₃O₄

[ Molecular Weight ]:
459.54

ORM-10962

Names

Biological Activity

Chemical & Physical Properties

Related Compounds