1-(3-Aminopropyl)-2-pyrrolidone

Names

[ Name ]:
1-(3-Aminopropyl)-2-pyrrolidone

[Synonym ]:
2-Pyrrolidinone, 1- (3-aminopropyl)-
1-(3-Aminopropyl)-2-pyrrolidinone
EINECS 231-632-7
2-Pyrrolidinone, 1-(3-aminopropyl)-
MFCD00003201
1-(3-Aminopropyl)-2-pyrrolidone
1-(3-aminopropyl)pyrrolidin-2-one

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
312.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₇H₁₄N₂O

[ Molecular Weight ]:
142.199

[ Flash Point ]:
132.4±22.6 °C

[ Exact Mass ]:
142.110611

[ PSA ]:
46.33000

[ LogP ]:
-0.75

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.503

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY5739500

CHEMICAL NAME :: 2-Pyrrolidinone, 1-(3-aminopropyl)-

CAS REGISTRY NUMBER :: 7663-77-6

BEILSTEIN REFERENCE NO. :: 0114960

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H14-N2-O

MOLECULAR WEIGHT :: 142.23

WISWESSER LINE NOTATION :: T5NVTJ A3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#05698

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C,Xi

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S27-S36/37/39-S45

[ RIDADR ]:
UN 3267 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
UY5739500

[ Hazard Class ]:
8.0

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

Total polyamines and their non-alpha-amino acid metabolites simultaneously determined in urine by capillary gas chromatography, with nitrogen-phosphorus detector; and some clinical applications.

Clin. Chem. 30(5) , 687-95, (1984)

A capillary gas-chromatographic method with nitrogen-phosphorus detection is used here to simultaneously determine 1,3-diaminopropane, putrescine, cadaverine, spermidine, spermine, isoputreanine , put...

Teratogenicity of valproate conjugates with anticonvulsant activity in mice.

Epilepsy Res. 57(2-3) , 145-52, (2003)

Valproic acid (VPA) is an effective antiepileptic medication, the use of which in females of childbearing age is complicated by its ability to induce birth defects, including neural tube defects (NTDs...

N-(3-aminopropyl)pyrrolidin-2-one: a physiological excretory product deriving from spermidine.

Int. J. Biochem. 15(7) , 907-15, (1983)

Normal human and rat urine contain N-(3-aminopropyl)pyrrolidin-2-one. This compound was identified by its chromatographic behaviour on a reversed phase column, by thin-layer chromatography of its dans...