Propionylpromazine hydrochloride

Names

[ Name ]:
Propionylpromazine hydrochloride

[Synonym ]:
PROPIOPROMAZINE HYDROCHLORIDE
Propionylpromazine hydrochloride

Biological Activity

[Description]:

Propionylpromazine hydrochloride (Propiopromazine hydrochloride), a dopamine receptor D2 (DRD2) antagonist, can be used in the research of Parkinson disease[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

D2 Receptor

[References]

[1]. Tyers, Mike, et al. Method for treating a brain cancer with ifenprodil. US8058243.

Chemical & Physical Properties

[ Boiling Point ]:
507.4ºC at 760 mmHg

[ Melting Point ]:
90-93ºC

[ Molecular Formula ]:
C₂₀H₂₅ClN₂OS

[ Molecular Weight ]:
376.94300

[ Flash Point ]:
260.7ºC

[ Exact Mass ]:
376.13800

[ PSA ]:
48.85000

[ LogP ]:
5.70070

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

Articles

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened...

[Electrocardiography alterations in horses caused by preanesthetic medication with combelen].

Berl. Munch. Tierarztl. Wochenschr. 93(9) , 163-6, (1980)