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Lavoltidine

Names

[ CAS No. ]:
76956-02-0

[ Name ]:
Lavoltidine

[Synonym ]:
LAVOLTIDINE
Lavoltidina
Lavoltidinum
[1-methyl-5-[3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino]-1,2,4-triazol-3-yl]methanol
Loxtidinum
Loxtidina
Loxtidine
Lavoltidinum [INN-Latin]
Loxtidinum [Latin]
Lavoltidine [INN:BAN]
Loxtidina [Spanish]

Biological Activity

[Description]:

Lavoltidine (Loxtidine) is an an orally active, irreversible and highly potent histamine H2-receptor antagonist. Lavoltidine strongly inhibits gastric acid secretion and also induces hypergastrinemia[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H2 Receptor


[In Vivo]

Lavoltidine (Loxtidine; 0.5 g/L; orally (drinking water); changed weekly; for 3 months) shows partial suppression of both gastric acid secretion and progression to neoplasia. Lavoltidine inhibits gastric atrophy, hyperplasia, and dysplasia in H felis-infected INS-GAS mice[1]. Lavoltidine treatment for 6 months inhibits gastric tumors in H felis-infected INS-GAS mice[1]. Animal Model: Male hypergastrinemic mice (INS-GAS mice) infected with Helicobacter felis[1] Dosage: 0.5 g/L Administration: Orally (drinking water); changed weekly; for 3 months Result: Showed partial suppression of both gastric acid secretion and progression to neoplasia.

[References]

[1]. Takaishi S, et al. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer.

Chemical & Physical Properties

[ Density]:
1.23g/cm3

[ Boiling Point ]:
566.9ºC at 760 mmHg

[ Molecular Formula ]:
C19H29N5O2

[ Molecular Weight ]:
359.46600

[ Flash Point ]:
296.6ºC

[ Exact Mass ]:
359.23200

[ PSA ]:
75.44000

[ LogP ]:
2.18520

[ Index of Refraction ]:
1.614

Related Compounds