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Garcinone C

Names

[ CAS No. ]:
76996-27-5

[ Name ]:
Garcinone C

[Synonym ]:
1,3,6,7-Tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
Garcinone C
9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-8-(3-hydroxy-3-methylbutyl)-2-(3-methyl-2-buten-1-yl)-

Biological Activity

[Description]:

Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia Champ that is used as an anti-inflammatory, analgesia, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR
Signaling Pathways >> JAK/STAT Signaling >> STAT
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR

[Target]

ATR

Stat-3

CDK7


[References]

[1]. Xia Y, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Mar;39(3):1485-1493.

Chemical & Physical Properties

[ Density]:
1.367

[ Boiling Point ]:
689.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C23H26O7

[ Molecular Weight ]:
414.448

[ Flash Point ]:
239.7±25.0 °C

[ Exact Mass ]:
414.167847

[ PSA ]:
131.36000

[ LogP ]:
3.40

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.656

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds