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Cycrimine

Names

[ CAS No. ]:
77-39-4

[ Name ]:
Cycrimine

[Synonym ]:
Cycriminum [INN-Latin]
Cicrimina
1-cyclopentyl-1-phenyl-3-piperidin-1-yl-propan-1-ol
Cicrimina [INN-Spanish]
Cycriminum
1-cyclopentyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
1-cyclopentyl-1-phenyl-3-piperidino-propan-1-ol
Pagitane
1-Cyclopentyl-1-phenyl-1-piperidino-propan-1-ol

Biological Activity

[Description]:

Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> mAChR
Signaling Pathways >> GPCR/G Protein >> mAChR
Research Areas >> Neurological Disease

[References]

[1]. David T. CHAU. Methods of treating behaviorial and/or mental disorders. WO2014176460A1.

[2]. Marzoughi S, et al. Tardive neurotoxicity of anticholinergic drugs: A review. J Neurochem. 2021 Sep;158(6):1334-1344.

[3]. Tacke, et al. Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism. Journal of organometallic chemistry 640.1-2 (2001): 140-165.

[4]. MAGEE KR, et al. Antispasmodic compound 08958 in treatment of paralysis agitans. J Am Med Assoc. 1953 Oct 24;153(8):715-8.

Chemical & Physical Properties

[ Density]:
1.057g/cm3

[ Boiling Point ]:
433.5ºC at 760 mmHg

[ Molecular Formula ]:
C19H29NO

[ Molecular Weight ]:
287.44000

[ Flash Point ]:
205.7ºC

[ Exact Mass ]:
287.22500

[ PSA ]:
23.47000

[ LogP ]:
3.87830

[ Index of Refraction ]:
1.554

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds