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10-Nitrolinoleic acid

Names

[ CAS No. ]:
774603-04-2

[ Name ]:
10-Nitrolinoleic acid

[Synonym ]:
(9E,12Z)-10-Nitro-9,12-octadecadienoic acid
9,12-Octadecadienoic acid, 10-nitro-, (9E,12Z)-
10-nitrolinoleic acid

Biological Activity

[Description]:

10-Nitrolinoleic acid is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleic acid competes with [3H]Rosiglitazone for binding to PPAR-γ, with an IC50 of 0.22 μM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease

[Target]

PPARγ:0.22 μM (IC50)


[References]

[1]. Dunny E, et, al. Stereocontrolled synthesis of the PPAR-gamma agonist 10-nitrolinoleic acid. J Org Chem. 2010 Aug 6;75(15):5334-6.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
452.2±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H31NO4

[ Molecular Weight ]:
325.443

[ Flash Point ]:
173.9±13.8 °C

[ Exact Mass ]:
325.225311

[ PSA ]:
83.12000

[ LogP ]:
6.10

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.493

[ Storage condition ]:
-20℃

Related Compounds