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Corylifol A

Names

[ CAS No. ]:
775351-88-7

[ Name ]:
Corylifol A

[Synonym ]:
4H-1-Benzopyran-4-one, 3-[3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-
3-{3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl}-7-hydroxy-4H-chromen-4-one

Biological Activity

[Description]:

Corylifol A inhibits IL-6-induced STAT3 activation and phosphorylation, with an IC50 of 0.81 μM.

[Related Catalog]:

Natural Products >> Flavonoids
Research Areas >> Others

[Target]

STAT3:0.81 μM (IC50)


[In Vitro]

Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells[1]. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC50s ranging between 4.2 and 38.4 μM[2]. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low Ki values ranging from 0.62 μM to 3.89 μM[3].

[References]

[1]. Lee SW, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 2012 Jun;78(9):903-6.

[2]. Kim DW, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29(1):59-63.

[3]. Li YG, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia. 2015 Jan 13;101C:99-106. d


[Related Small Molecules]

Tyrphostin B42 (AG-490) | Stattic | AS1517499 | S3I-201 | Cryptotanshinone | Napabucasin | Homoharringtonine | STAT5-IN-1 | WP1066 | Niclosamide | BP-1-102 | Scutellarin | SH-4-54 | HO-3867 | Artesunate

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
609.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H26O4

[ Molecular Weight ]:
390.471

[ Flash Point ]:
208.8±25.0 °C

[ Exact Mass ]:
390.183105

[ PSA ]:
70.67000

[ LogP ]:
6.91

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
-20°C

Related Compounds