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HO-PEG10-CH2CH2COO<sup>t</sup>Bu

Names

[ CAS No. ]:
778596-26-2

[ Name ]:
HO-PEG10-CH2CH2COO<sup>t</sup>Bu

[Synonym ]:
HO-PEG10-CH2CH2COOtBu

Biological Activity

[Description]:

Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024)[1]. Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011)[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Huli, et al. A kind of preparation method of hydroxyl polyethylene glycol propionic ester. Patent

[2]. Miller ML, et al. Synthesis of taxoids with improved cytotoxicity and solubility for use in tumor-specific delivery.J Med Chem. 2004 Sep 23;47(20):4802-5.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H54O13

[ Molecular Weight ]:
586.71000

[ Exact Mass ]:
586.35600

[ PSA ]:
138.83000

[ LogP ]:
0.87650

Related Compounds