Roxatidine

Names

[ Name ]:
Roxatidine

[Synonym ]:
ROXATIDINE ENTERPRISE STANDARD
MFCD00871807
desacetyl-TZU-0460

Biological Activity

[Description]:

Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[References]

[1]. Lee M, et al. Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation. Sci Rep. 2017;7:41721. Published 2017 Jan 31.

Chemical & Physical Properties

[ Density]:
1.137 g/cm3

[ Boiling Point ]:
524.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₇H₂₆N₂O₃

[ Molecular Weight ]:
306.40000

[ Flash Point ]:
270.9ºC

[ Exact Mass ]:
306.19400

[ PSA ]:
61.80000

[ LogP ]:
1.87870

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%