FKK

Names

[ Name ]:
FKK

[Synonym ]:
7-Methyl-9-phenyl-2,3-dihydro-1H-pyrazolo[1,2-a]indazol-10-ium bromide hydrate (1:1:1)
1H-Pyrazolo[1,2-a]indazol-10-ium, 2,3-dihydro-7-methyl-9-phenyl-, bromide, hydrate (1:1:1)

Biological Activity

[Description]:

FKK is an indazole derivative and also a novel bronchodilator.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Cardiovascular Disease

Research Areas >> Inflammation/Immunology

[In Vivo]

FKK is an indazole derivative and also a novel bronchodilator. FKK (0.1 to 3.0 mg/kg, i.v.) slightly increases respiratory frequency, left ventricular (LV) dp/dt max and myocardial contractile force. A slight increase followed by a decrease is observed in systemic blood pressure and LV systolic pressure. FKK causes direct vasodilation in the coronary, mesenteric and femoral vasculatures, but has no effect on the renal vasculature. It is particularly pertinent that FKK (30 mg/kg, i.d., enough to cause marked bronchodilation), unlike aminophylline (30 mg/kg, i.d.), does not significantly influence the cardiovascular system[1].

[References]

[1]. Shiraki Y, et al. Effects of an indazole derivative, FKK, a novel bronchodilator, on the cardiovascular system in dogs. Arch Int Pharmacodyn Ther. 1985 Jan;273(1):155-66.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₇BrN₂

[ Molecular Weight ]:
329.23

[ Storage condition ]:
2-8℃