A2B receptor antagonist 2

Names

[ CAS No. ]:
784-90-7

[ Name ]:
A2B receptor antagonist 2

[Synonym ]:
GNF-Pf-1241
2-Guanidino-4.6.7-trimethyl-chinazolin

Biological Activity

[Description]:

A2B receptor antagonist 2 (compound 18) is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[References]

[1]. Thomas R Webb, et al. Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors. Bioorg Med Chem. 2003 Jan 2;11(1):77-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₅N₅

[ Molecular Weight ]:
229.28

[ Exact Mass ]:
229.13300

[ PSA ]:
87.68000

[ LogP ]:
2.73340

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%