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7-CHLORO-2-(PYRIDIN-3-YL)-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

Names

[ CAS No. ]:
786-97-0

[ Name ]:
7-CHLORO-2-(PYRIDIN-3-YL)-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE

[Synonym ]:
SU-10,603
C15H12ClNO

Biological Activity

[Description]:

SU 10603 is a specific inhibitor of P45017α (P450c17; CYP17A1)[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Metabolic Disease

[References]

[1]. Hojo Y, et al. Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):865-70.

Chemical & Physical Properties

[ Density]:
1.275g/cm3

[ Boiling Point ]:
430.1ºC at 760 mmHg

[ Molecular Formula ]:
C15H12ClNO

[ Molecular Weight ]:
257.71

[ Flash Point ]:
213.9ºC

[ Exact Mass ]:
257.06100

[ PSA ]:
29.96000

[ LogP ]:
3.64770

[ Index of Refraction ]:
1.615