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2-Naphthol-d7

Names

[ CAS No. ]:
78832-54-9

[ Name ]:
2-Naphthol-d7

[Synonym ]:
MFCD01074243
2-Naphthol-1,3,4,5,6,7,8-d7
2-naphthol-d7

Biological Activity

[Description]:

2-Naphthol-d7 is the deuterium labeled 2-Naphthol[1]. 2-Naphthol is a metabolite of naphthalene, catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1, CYP 1A2, CYP 2A1, CYP 2E1 and CYP 2F2)[2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Kapuci M, et al. Determination of cytotoxic and genotoxic effects of naphthalene, 1-naphthol and 2-naphthol on human lymphocyte culture. Toxicol Ind Health. 2014 Feb;30(1):82-9.  

Chemical & Physical Properties

[ Density]:
1.239g/cm3

[ Boiling Point ]:
285-286ºC(lit.)

[ Melting Point ]:
120-122ºC(lit.)

[ Molecular Formula ]:
C10HD7O

[ Molecular Weight ]:
151.21300

[ Flash Point ]:
144ºC

[ Exact Mass ]:
151.10100

[ PSA ]:
20.23000

[ LogP ]:
2.54540

[ Index of Refraction ]:
1.677

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H332-H400

[ Precautionary Statements ]:
P261-P301 + P312 + P330

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 3077 9 / PGIII

Precursor & DownStream

Precursor

DownStream

Related Compounds