Chicanine

Names

[ Name ]:
Chicanine

[Synonym ]:
Phenol, 4-[(2S,3R,4S,5S)-5-(1,3-benzodioxol-5-yl)tetrahydro-3,4-dimethyl-2-furanyl]-2-methoxy-
4-[(2S,3R,4S,5S)-5-(1,3-Benzodioxol-5-yl)-3,4-dimethyltetrahydro-2-furanyl]-2-methoxyphenol
chicanine
4-((2S,3R,4S,5S)-5-Benzo[1,3]dioxol-5-yl-3,4-dimethyl-tetrahydro-furan-2-yl)-2-methoxy-phenol
Chicanin

Biological Activity

[Description]:

Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> IKK

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Research Areas >> Inflammation/Immunology

Signaling Pathways >> MAPK/ERK Pathway >> ERK

Signaling Pathways >> Stem Cell/Wnt >> ERK

[References]

[1]. Chicanine, et al. Anti-inflammatory effects of chicanine on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways. Eur J Pharmacol. 2014 Feb 5;724:168-74.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
483.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂O₅

[ Molecular Weight ]:
342.386

[ Flash Point ]:
246.4±28.7 °C

[ Exact Mass ]:
342.146729

[ PSA ]:
57.15000

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.575