KRM-III

Names

[ Name ]:
KRM-III

[Synonym ]:
1,4-diphenyl-1H-imidazole-2-thiol
KRM-III
1,4-phenyl-1H-imidazole-2-thiol

Biological Activity

[Description]:

KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Eun Joo Jung, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331(3):1005-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₂N₂S

[ Molecular Weight ]:
252.33400

[ Exact Mass ]:
252.07200

[ PSA ]:
56.62000

[ LogP ]:
3.82800

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport