DMHAPC-Chol
Names
[ CAS No. ]:
794494-38-5
[ Name ]:
DMHAPC-Chol
Biological Activity
[Description]:
DMHAPC-Chol is a cationic cholesterol. Liposomes containing DMHAPC-chol have been used for DNA plasmid delivery in vitro and in vivo in a B16-F10 mouse xenograft model. Liposomes containing DMHAPC-chol are cytotoxic to B16-F10 cells. DMHAPC-Chol, as part of a lipoplex with DOPE, has also been used to deliver DNA into mouse lung via intratracheal injection, resulting in a heterogeneous distribution in the bronchi and bronchioles, and to deliver VEGF siRNA into A431 and MDA-MB-231 cells, which secrete VEGF.
Chemical & Physical Properties
[ Molecular Formula ]:
C35H63N2O3
[ Molecular Weight ]:
559.9