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Mioflazine

Names

[ CAS No. ]:
79467-23-5

[ Name ]:
Mioflazine

[Synonym ]:
3-(Aminocarbonyl)-4-[4,4-bis(4-fluorophenyl)butyl]-N-(2,6-dichlorophenyl)-1-piperazineacetamide

Biological Activity

[Description]:

Mioflazine is an orally active nucleoside transport inhibitor, can be used to treat sleep disorders. Mioflazine inhibits nucleoside uptake[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Wauquier A, et al. Sleep improvement in dogs after oral administration of mioflazine, a nucleoside transport inhibitor. Psychopharmacology (Berl). 1987;91(4):434-9.

[2]. Pirovano IM, et al. Inhibition of nucleoside uptake in human erythrocytes by a new series of compounds related to lidoflazine and mioflazine. Eur J Pharmacol. 1990 Dec 15;189(6):419-22.

Chemical & Physical Properties

[ Density]:
1.329g/cm3

[ Boiling Point ]:
763.6ºC at 760 mmHg

[ Molecular Formula ]:
C29H30Cl2F2N4O2

[ Molecular Weight ]:
575.47700

[ Flash Point ]:
415.6ºC

[ Exact Mass ]:
574.17100

[ PSA ]:
78.67000

[ LogP ]:
5.94300

[ Index of Refraction ]:
1.606

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds