DM3

Names

[ CAS No. ]:
796073-54-6

[ Name ]:
DM3

Biological Activity

[Description]:

DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Maytansinoids


[References]

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
942.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C37H52ClN3O10S

[ Molecular Weight ]:
766.341

[ Flash Point ]:
523.6±34.3 °C

[ Exact Mass ]:
765.306213

[ LogP ]:
5.37

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.592

Related Compounds