CRF (ovine)

Corticotropin-releasing factor (ovine) is a preferential CRF1 receptor agonist. Sequence: Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2.

Signaling Pathways >> Others >> Others

Research Areas >> Cancer

Peptides

CRF1 receptor[1].

Corticotropin-releasing factor (ovine), a preferential CRF1 receptor agonist, shows almost 200-fold greater affinity for the CRF1 than CRF2 receptor[1].

Corticotropin-releasing factor (ovine) (Ovine CRF: 0.1-2.5 nM) stimulates corticotropin release by pituitaries of Wistar rats and this effect is augmented two- to three fold in the presence of arginine vasopressin (0.09-0.9 mIU/ml) or oxytocin (0.9-90 mIU/ml) [2]. oCRF (10 μg) suppresses 6-h intake of cafeteria diet-fed rats without regard to macronutrient composition. Rather, oCRF most potently suppresses intake of preferred food items[1].

[1]. Eric P. Zorrilla et al. Human Urocortin 2, a Corticotropin-Releasing Factor (CRF)2 Agonist, and Ovine CRF, a CRF1 Agonist, Differentially Alter Feeding and Motor Activity. Journal of Pharmacology and Experimental Therapeutics September 2004, 310 (3) 1027-1034;

[2]. Antoni FA et al. Oxytocin as well as vasopressin potentiate ovine CRF in vitro. Peptides. 1983 Jul-Aug;4(4):411-5.

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