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Head activator

Names

[ CAS No. ]:
79943-68-3

[ Name ]:
Head activator

Biological Activity

[Description]:

Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

GPR37[1]


[In Vitro]

Head activator neuropeptide (2 nM，0-60 分钟) 在转染了 GPR37-FLAG 的 COS-7 细胞中刺激 GPR37 的内化[1]。 Head activator neuropeptide (EC50: 3.3 nM) 增加转染载脂蛋白和 GPR37[1] 的 CHO-K1 细胞中的 Ca2+ mobilisation[1]。 Head activator neuropeptide (EC50: 5.6 nM) 刺激表达 GPR37 的青蛙卵母细胞的电流增加[1]。

[References]

[1]. Rezgaoui M, et al. The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. J Cell Sci. 2006 Feb 1;119(Pt 3):542-9.  

Chemical & Physical Properties

[ Density]:
1.271g/cm3

[ Boiling Point ]:
1506.5ºC at 760 mmHg

[ Molecular Formula ]:
C54H84N12O14

[ Molecular Weight ]:
1125.32000

[ Flash Point ]:
864.9ºC

[ Exact Mass ]:
1124.62000

[ PSA ]:
386.07000

[ LogP ]:
1.61710

[ Index of Refraction ]:
1.564

Safety Information

[ WGK Germany ]:
3

Related Compounds