5-Carboxyfluorescein Diacetate

Names

[ Name ]:
5-Carboxyfluorescein Diacetate

[Synonym ]:
3',6'-Diacetoxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid
5(6)-carboxyfluorescein diacetate
MFCD00036872
Spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid, 3',6'-bis(acetyloxy)-3-oxo-
5-CFDA

Biological Activity

[Description]:

5-CFDA(5-Carboxyfluorescein diacetate) is membrane-permeant and can be loaded into cells via incubation; hydrolyzed by intracellular esterases to 5-carboxyfluorescein; used for labeling human intervertebral disk cells in vitro for fluorescence microscopy.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
693.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₁₆O₉

[ Molecular Weight ]:
460.389

[ Flash Point ]:
241.9±25.0 °C

[ Exact Mass ]:
460.079437

[ PSA ]:
125.43000

[ LogP ]:
2.40

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.702

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R45;R46;R23/24/25;R36/37/38

[ Safety Phrases ]:
53-22-26-36/37/39-45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

J. Med. Chem. 51 , 3275-87, (2008)

The chemical space of registered oral drugs was explored for inhibitors of the human multidrug-resistance associated protein 2 (MRP2; ABCC2), using a data set of 191 structurally diverse drugs and dru...

Phylloxera (Daktulosphaira vitifoliae Fitch) alters the carbohydrate metabolism in root galls to allowing the compatible interaction with grapevine (Vitis ssp.) roots.

Plant Sci. 234 , 38-49, (2015)

Gall forming phylloxera may compete for nutrients with meristematic tissues and develop heterotrophic structures that act as carbon sinks. In this work, we studied the underlying starch metabolism, si...

Upregulation of Multidrug Resistance-Associated Protein 1 by Allyl Isothiocyanate in Human Bronchial Epithelial Cell: Involvement of c-Jun N-Terminal Kinase Signaling Pathway.

Oxid. Med. Cell. Longev. 2015 , 903782, (2015)

Multidrug resistance-associated protein 1 (MRP1) plays a protective role in the etiology and progression of chronic obstructive pulmonary disease (COPD) which results from oxidative stress and inflamm...