sulfisoxazole acetyl (200 mg)

Names

[ CAS No. ]:
80-74-0

[ Name ]:
sulfisoxazole acetyl (200 mg)

[Synonym ]:
GANTRISIN PEDIATRIC
Acetyl-(3,4-dimethyl-isoxazol-5-yl)-sulfanilyl-amin
Sulfisoxazole acetyl
Lipo Gantrisin
N-(4-amino-benzenesulfonyl)-N-(3,4-dimethyl-isoxazol-5-yl)-acetamide
N-3,4-dimethylisoxazol-5-yl-N-sulfanilylacetamide
UNII-WBT5QH3KED
EINECS 201-305-3
Sulfisoxazole acetal
acetylsulfafurazole
ACETYL SULFISOXAZOLE

Biological Activity

[Description]:

Sulfisoxazole acetyl (N1-Acetylsulfisoxazole), a Sulfisoxazole derivative, is an orally active dihydropteroate synthase inhibitor. Sulfisoxazole acetyl has an antibacterial action[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

As with other sulfonamides, the antibacterial action of Sulfisoxazole acetyl (N1-Acetylsulfisoxazole) is attributable to inhibiting dihydropteroate synthase, a key enzyme in folate synthesis in bacteria. Sulfisoxazole acetyl is known to be transformed primarily to sulfisoxazole, partly to N4-acetyl sulfisoxazole (N4AS), and likely also to diacetyl sulfisoxazole (DAS) and other compounds[1].

[References]

[1]. Eunyoung Kim, et al. Simultaneous determination of N(1)-acetyl sulfisoxazole and its metabolites, and relative bioavailability compare to sulfisoxazole in rats. J Pharm Biomed Anal. 2016 Sep 10;129:117-120.

Chemical & Physical Properties

[ Density]:
1.404g/cm3

[ Melting Point ]:
193-194°

[ Molecular Formula ]:
C₁₃H₁₅N₃O₄S

[ Molecular Weight ]:
309.34100

[ Exact Mass ]:
309.07800

[ PSA ]:
114.88000

[ LogP ]:
3.27740

[ Index of Refraction ]:
1.611

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%