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Lysine-methotrexate

Names

[ CAS No. ]:
80407-56-3

[ Name ]:
Lysine-methotrexate

[Synonym ]:
(S)-6-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-hexanoic acid

Biological Activity

[Description]:

Lysine-methotrexate, an analogue of Methotrexate (HY-14519), is a dihydrofolate reductase (DHFR) inhibitor[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Antifolate
Research Areas >> Inflammation/Immunology

[References]

[1]. Kempton RJ, et al. Lysine and ornithine analogues of methotrexate as inhibitors of dihydrofolate reductase. J Med Chem. 1982 Apr;25(4):475-7.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H27N9O3

[ Molecular Weight ]:
453.49800

[ Exact Mass ]:
453.22400

[ PSA ]:
199.26000

[ LogP ]:
2.78620

Related Compounds