Pancreatin

Names

[ Name ]:
Pancreatin

[Synonym ]:
(9cis)-Retinoic acid
Alitretinoin
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
9-cis-retinoic acid
intrazyme
9Z-retinoic acid
ilozyme
pankreon
9-cis-Tretinoin
Retinoic acid, (9cis)-
beefviokase
diastasevera
panteric
EINECS 232-468-9
pancrex-v
pankrotanon
9(Z)-Retinoic acid

Biological Activity

[Description]:

Pancreatin is the porcine pancreas extract (PPE) which contains the main pancreatic digestive enzymes.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Endocrinology

[In Vitro]

Pancreatin is the porcine pancreas extract (PPE) which contains the main pancreatic digestive enzymes. The amount of free fatty acids (FFAs) titrated at pH 6.5 does increase by 120 and 28% for II-LC and IIIA-LC, respectively, when Pancreatin is increased from 150 to 900 USP U/mL, and the total extent of lipolysis increases by 79 and 28% II-LC and IIIA-LC, respectively. By elevating Pancreatin activity from 150 to 900 USPU/mL, the total extent of digestion on average for LC-LBFs increases by 51%, whereas the amount of FFAs detected at pH 6.5 increases by 55% on average. An increase in extent of digestion is also observed with increasing Pancreatin levels[1].

[References]

[1]. Sassene P, et al. Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels. AAPS J. 2014 Nov;16(6):1344-57.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
462.8±14.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₈O₂

[ Molecular Weight ]:
300.435

[ Flash Point ]:
350.6±11.0 °C

[ Exact Mass ]:
300.208923

[ LogP ]:
6.83

[ Appearance of Characters ]:
powder | beige

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.556

[ Storage condition ]:
−20°C

[ Stability ]:
Stable. Incompatible with alcohols, strong acids.

[ Water Solubility ]:
Soluble or partly soluble in water forming a slightly turbid solution; practically insoluble in ethanol (96%) and in ether . | Soluble in water. Insoluble in alcohol and ether.

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P284-P304 + P340-P305 + P351 + P338-P342 + P311

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
36/37/38-42-42/43

[ Safety Phrases ]:
S24;S26;S36/S37;S37/S39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
RT9033000

Articles

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Effects of treating corn and wheat distillers dried grains with solubles (DDGS) with a multicarbohydrase alone or in combination with a protease on porcine in vitro fermentation characteristics and th...