vitamin D3-d3

Names

[ Name ]:
vitamin D3-d3

[Synonym ]:
vitamin-d3-[2h3]

Biological Activity

[Description]:

Vitamin D3-d3 is the deuterium labeled Vitamin D3. Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Vitamin D Related >> VD/VDR

Research Areas >> Metabolic Disease

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Nazik Al-Hashimi, et al. Cholecalciferol;Laura Bergadà, et al. Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma. Lab Invest. 2014 Jun;94(6):608-22;Hiroki Yoshioka,

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₄₁D₃O

[ Molecular Weight ]:
387.65600

[ Exact Mass ]:
387.35800

[ PSA ]:
20.23000

[ LogP ]:
7.61900

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H319

[ Precautionary Statements ]:
P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

[ RIDADR ]:
UN1170 - class 3 - PG 2 - Ethanol, solution

Articles

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

J. Chromatogr. A. 1364 , 214-22, (2014)

We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of...