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Zingibroside R1

Names

[ CAS No. ]:
80930-74-1

[ Name ]:
Zingibroside R1

[Synonym ]:
28-deglucosyl-chikusetsusaponin V
Zingibroside R1
polysciassaponin P5
3-O-[O-β-D-glucopyranosyl-(1->2)-(β-D-glucopyranosyluronic acid)]oleanolic acid
polysciasaponin P5

Biological Activity

[Description]:

Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity[1].Zingibroside R1 possesses some anti-HIV-1 activity.Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC50=91.3 μM)[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Research Areas >> Metabolic Disease

[Target]

IC50: 91.3 μM (2-DG uptake)[1]


[References]

[1]. Yoshizaki K, et al. Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). Chem Pharm Bull (Tokyo). 2013;61(3):344-50. Epub 2012 Dec 28

[2]. Hasegawa H, et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60 (3):240-3.

Chemical & Physical Properties

[ Density]:
1.37±0.1 g/cm3

[ Molecular Formula ]:
C42H66O14

[ Molecular Weight ]:
794.96500

[ Exact Mass ]:
794.44500

[ PSA ]:
232.90000

[ LogP ]:
2.97430

[ Storage condition ]:
2-8℃

[ Water Solubility ]:
Insuluble (1.8E-4 g/L) (25 ºC)

Related Compounds