DL-threo-PDMP (hydrochloride)

Names

[ Name ]:
DL-threo-PDMP (hydrochloride)

[Synonym ]:
d,l-threo-pdmp hcl
N-[(1R,2R)-1-Hydroxy-3-(4-morpholinyl)-1-phenyl-2-propanyl]decanamide hydrochloride (1:1)
dl-pdmp
pdmp hydrochloride glucosylceramide sy nthase inhibitor
1-phenyl-2-decanoylamino-3-morpholino-1-propanol,hcl
dl-threo-pdmp,hydrochloride
Decanamide, N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-, hydrochloride (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
607.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₃₉ClN₂O₃

[ Molecular Weight ]:
427.020

[ Flash Point ]:
321.2ºC

[ Exact Mass ]:
426.264923

[ PSA ]:
61.80000

[ LogP ]:
4.80850

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells.

J. Cell Physiol. 141 , 573-583, (1989)

Incubating B16 melanoma cells with an inhibitor of glucosylceramide (GlcCer) synthetase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP), led to a considerable decrease in the ...

Inhibition of glycosphingolipid synthesis by threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) and the modulation of IL-1beta-stimulated expression of inducible nitric oxide synthase in rat aortic smooth muscle cells.

Br. J. Pharmacol. 123 , 906-910, (1998)

1. The composition of glycosphingolipids is altered in atherosclerotic tissue. In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide sy...

Radin, et al.

J. Lipid Res. 26 , 183-213, (1993)