Pivopril
Names
Biological Activity
[Description]:
Pivalopril is a new orally active angiotensin converting enzyme (ACE) inhibitor.
[Related Catalog]:
[Target]
ACE[1]
[In Vivo]
Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. In separate groups of conscious normotensive rats, Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. In conscious normotensive dogs, Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. At equieffective doses the two compounds have similar durations of action. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent[2].
[References]
[Related Small Molecules]
Angiotensin I/II (1-7) trifluoroacetate salt
|
Captopril
|
Enalapril maleate
|
Perindopril erbumine
|
Lisinopril diydrate
|
Phosphoramidon disodium salt
|
Trandolapril
|
Fosinopril sodium
|
Quinapril hydrochloride
|
Ramipril
|
Cilazapril Monohydrate
|
Enalaprilat Dihydrate
|
omapatrilat
|
Temocapril (hydrochloride)
|
Hemorphin-7
Chemical & Physical Properties
[ Density]:
1.16g/cm3
[ Boiling Point ]:
490.431°C at 760 mmHg
[ Molecular Formula ]:
C16H27NO4S
[ Molecular Weight ]:
329.45500
[ Flash Point ]:
250.4±26.8 °C
[ Exact Mass ]:
329.16600
[ PSA ]:
99.98000
[ LogP ]:
2.78420
[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C
[ Index of Refraction ]:
1.531
[ Storage condition ]:
2-8℃