2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-

Names

[ Name ]:
2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-

Biological Activity

[Description]:

EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC50 of 5.5 nM and a Ki of 6.8 nM. EMD 495235 shows anticoagulant activities[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[Target]

IC50: 5.5 nM (factor Xa)[1]. Ki: 6.8 nM (human factor Xa)[1].

[References]

[1]. Werner W K R Mederski, et al. Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5817-22.

Chemical & Physical Properties

[ Density]:
1.393g/cm3

[ Boiling Point ]:
786.902ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₂ClN₃O₅S

[ Molecular Weight ]:
451.92

[ Flash Point ]:
429.703ºC

[ Exact Mass ]:
451.09700

[ PSA ]:
125.21000

[ LogP ]:
2.98550

[ Index of Refraction ]:
1.625

2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-

Names

Biological Activity

Chemical & Physical Properties

Related Compounds