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3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone

Names

[ CAS No. ]:
812647-88-4

[ Name ]:
3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-2-(2-pyridinylmethylene)-4-thiazolidinone

[Synonym ]:
(2Z,5E)-3-Ethyl-5-(3-methyl-1,3-benzothiazol-2-ylidene)-2-(pyridin-2-ylmethylidene)-1,3-thiazolidin-4-one

Biological Activity

[Description]:

YM-08 (Compounds 7a) is a brain-penetrant inhibitors of SIRT2,with the IC50 of 19.9 μM. YM-08 also is inhibitor of Hsp70[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Research Areas >> Neurological Disease

[Target]

HSP70


[References]

[1]. Abbotto E, et al. Novel Thiazole-Based SIRT2 Inhibitors Discovered via Molecular Modelling Studies and Enzymatic Assays. Pharmaceuticals (Basel). 2023;16(9):1316. Published 2023 Sep 18.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H17N3OS2

[ Molecular Weight ]:
367.49

[ Water Solubility ]:
Soluble in DMSO

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds