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Momordicoside G

Names

[ CAS No. ]:
81371-54-2

[ Name ]:
Momordicoside G

[Synonym ]:
(1R,4S,5S,8R,9R,12S,13S,16S)-8-[(2R,4E)-6-Methoxy-6-methyl-4-hepten-2-yl]-5,9,17,17-tetramethyl-18-oxapentacyclo[10.5.2.0.0.0]nonadec-2-en-16-yl β-D-allopyranoside
momordicoside G
β-D-Allopyranoside, (3S,5R,8S,9S,10S,13R,14S,17R)-1,3,4,8,10,11,12,13,14,15,16,17-dodecahydro-17-[(1R,3E)-5-methoxy-1,5-dimethyl-3-hexen-1-yl]-4,4,13,14-tetramethyl-5,9-(epoxymethano)-2H-cyclopenta [a]phenanthren-3-yl
Momorcharaside A

Biological Activity

[Description]:

Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Inflammation/Immunology

[In Vitro]

用 10 ng/mL LPS 或 10 ng/mL IL-10 刺激 Raw264.7 巨噬细胞 24 h，获得 M1 样 (iNOS+) 和 M2样 (精氨酸酶+) 巨噬细胞[1]。 Momordicoside G (10-40 μM; 24 h) 抑制 M1 巨噬细胞的细胞活力，对 M2 巨噬细胞无抑制作用。Momordicoside G (40 μM) 体外诱导 M1 巨噬细胞凋亡，降低 NO 水平，增加 IL-12、IL-10 和 TGF-β 水平[1]。 Momordicoside G (40 μM) 可抑制细胞自噬相关标志物 LC3-B 的蛋白水平[1]。 Cell Viability Assay[1] Cell Line: M1 macrophages, M2 macrophages Concentration: 10 μM, 20 μM, 40 μM Incubation Time: 24 hours Result: Selectively decreased the cell viability of M1 macrophages, instead of M2 macrophages.

[In Vivo]

ICR 小鼠的肺部致癌模型由氨基甲酸乙酯 (HY-B1207) (600 mg/kg；腹腔注射；每周一次，持续 4 或 8 周) 诱导，或由 LPS (HY-D1056) (2 mg/kg；气管内施用) 和 4 mg/小鼠 IEC (腹腔注射) 诱导[1]。 Momordicoside G (50 mg/kg；口服；每天一次，持续 4 或 8 周) 在小鼠肺致癌模型中可预防氨基甲酸乙酯引起的肺损伤和癌病变[1]。 Momordicoside G (50 mg/kg；口服；每天一次，持续 2 周) 在 LPS 诱导的肺损伤模型中促进肺损伤修复[1]。 Animal Model: Mouse lung carcinogenic model: Urethane-induced lung carcinogenic model and LPS-induced lung injury model[1] Dosage: 50 mg/kg Administration: Oral gavage; once daily for 4 or 8 weeks Result: Affected inflammasome and cytokines during urethane-induced lung injury and carcinoma lesions. Exhibits macrophage-regulating capacity in LPS-induced lung injury model.

[References]

[1]. Du Z, et al. Momordicoside G Regulates Macrophage Phenotypes to Stimulate Efficient Repair of Lung Injury and Prevent Urethane-Induced Lung Carcinoma Lesions. Front Pharmacol. 2019 Mar 29;10:321.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
711.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C37H60O8

[ Molecular Weight ]:
632.867

[ Flash Point ]:
384.0±32.9 °C

[ Exact Mass ]:
632.428833

[ PSA ]:
117.84000

[ LogP ]:
5.40

[ Vapour Pressure ]:
0.0±5.2 mmHg at 25°C

[ Index of Refraction ]:
1.574

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds