(2S)-2-amino-5-[[(2R)-1-(hydroxycarbonylmethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid

Names

[ Name ]:
(2S)-2-amino-5-[[(2R)-1-(hydroxycarbonylmethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid

[Synonym ]:
L-Glutamyl-L-cysteinyl-glycine-13C2,15N1
Glutathione-(glycine-13C2,15N)
Glutathione-glycine-13C2,15N1

Biological Activity

[Description]:

L-Glutathione reduced-13C2,15N (GSH-13C2,15N) is the 13C- and 15N-labeled L-Glutathione reduced. L-Glutathione reduced (GSH) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Apoptosis >> Ferroptosis

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Pereira-Rodrigues N, et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH. Bioelectrochemistry. 2007 Jan;70(1):147-54.

Chemical & Physical Properties

[ Melting Point ]:
200-202ºC (dec.)

[ Molecular Formula ]:
C₁₀H₁₇N₃O₆S

[ Molecular Weight ]:
310.30200

[ Exact Mass ]:
310.08800

[ PSA ]:
197.62000

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26