m-PEG5-acid

Names

[ CAS No. ]:
81836-43-3

[ Name ]:
m-PEG5-acid

[Synonym ]:
mPEG4-CH2CH2COOH
4,7,10,13,16-Pentaoxaheptadecanoic acid

Biological Activity

[Description]:

m-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₂₄O₇

[ Molecular Weight ]:
280.31500

[ Exact Mass ]:
280.15200

[ PSA ]:
83.45000

[ LogP ]:
0.17390

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi