NSC 33994
Names
[ CAS No. ]:
82058-16-0
[ Name ]:
NSC 33994
[Synonym ]:
4,4'-[(1E)-1,2-Diethyl-1,2-ethenediyl]bis[2-[(diethylamino)methyl]phenol
(E)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
4,4 inverted exclamation marka-(3E)-Hex-3-ene-3,4-diylbis{2-[(diethylamino)methyl]phenol}
Biological Activity
[Description]:
[Related Catalog]:
[Target]
JAK2:60 nM (IC50, JAK2 Val617Phe kinase activity )
[In Vitro]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C28H42N2O2
[ Molecular Weight ]:
438.64500
[ Exact Mass ]:
438.32500
[ PSA ]:
46.94000
[ LogP ]:
6.51220
MSDS
Safety Information
[ RIDADR ]:
NONH for all modes of transport
Synthetic Route
Articles
Oncotarget 5(15) , 6038-48, (2014)
Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. It is also expressed in normal epithelial linings of the gastrointestinal trac...
RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer.Oncotarget 6 , 11114-24, (2015)
We have demonstrated that RNA-dependent protein kinase (PKR) and its downstream protein p-eIF2α are independent prognostic markers for overall survival in lung cancer. In the current study, we further...
Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.Toxicol. In Vitro 29(3) , 417-25, (2015)
Plant-derived dietary polyphenolic compounds, such as flavonoids, with cancer cell-specific pro-apoptotic activity and chemopreventive potential are thought to be promising anticancer agents. In the p...