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SN 2

Names

[ CAS No. ]:
823218-99-1

[ Name ]:
SN 2

[Synonym ]:
5-Mesityl-3-oxa-4-azatricyclo[5.2.1.02,6]dec-4-ene
4,7-Methano-1,2-benzisoxazole, 3a,4,5,6,7,7a-hexahydro-3-(2,4,6-trimethylphenyl)-
MFCD05739166
MFCD09266779

Biological Activity

[Description]:

SN 2 is a novel and potent activator of TRPML3 ion channel with EC50 of 1.8±0.13 μM.

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Others

[Target]

EC50: 1.8±0.13 μM (TRPML3), >29.9 μM (TRPML1)[1]


[In Vitro]

The conductance of TRPML3 channels is estimate, when activated with 10 µM SN-2 is approximately 10 pS at −80 mV. TRPML3-expressing HEK293 cells are perfused with a series starting with compound alone (in SBS), with compound in ELS, and finally with ELS alone. Two representative compounds, SF-24 and SN-2, are tested. SF-24 is one of the least effective compounds, and SN-2 is one of the most active ones. SN-2 has a similar synergistic effect, also reaching up-to 10-fold enhancement of the combined response when compared with the individual responses, reaching average current densities of up to 3 nA/pF at −80 mV. Dominant negative TRPML3(D458K) is highly effective in eliminating SN-2-induced activity in epidermal melanocytes, suggesting that SN-2 activates a channel that is not responsive in presence of TRPML3(D458K). Such a dominant negative action might be attributed to potential heteromerization of TRPML3(D458K) with an SN-2-responsive channel[1].

[References]

[1]. Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.


[Related Small Molecules]

capsaicin | Capsazepine | EIPA | Diphenyleneiodonium chloride | HC-030031 | SKF-96365 | HC 067047 | AMG 9810 | GSK-1016790A | SAR7334 | PF-4840154 | RN-1734 | AMG-517 | SB-366791 | IcilinAG-3-5

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
370.8±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H21NO

[ Molecular Weight ]:
255.355

[ Flash Point ]:
144.5±23.2 °C

[ Exact Mass ]:
255.162308

[ LogP ]:
4.25

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.665

[ Storage condition ]:
2-8℃

Related Compounds