Humantenmine

Names

[ Name ]:
Humantenmine

[Synonym ]:
(3S,3'R,3a'S,6'R,8a'S)-2'-ethyl-1-methoxy-3a',4',8',8a'-tetrahydro-3'H,6'H-spiro[indole-3,7'-[3,6]methanooxepino[4,3-b]pyrrol]-2(1H)-one
Gelsedine, 4,20-didehydro-
(1'R,3S,4'S,7'R,8'S)-6'-Ethyl-1-methoxyspiro[indole-3,2'-[10]oxa[5]azatricyclo[5.3.1.0]undec[5]en]-2(1H)-one

Biological Activity

[Description]:

Humantenmine, a newalkaloid isolated from Gelsemium elegan Banth in China, has the potential for pain and rheumatic arthritis treatment[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

Humantenmine (HMT) decreases the 14-day survival rate of the mice to 17% after they are intragastrically treated with HMT, along with hepatic injury and increasing alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels. CYP3A4/5 mediates the metabolism and detoxification of HMT[1][2].

[References]

[1]. Kun Yang, et al. Development and In-House Validation of a Sensitive LC-MS/MS Method for Simultaneous Quantification of Gelsemine, Koumine and Humantenmine in Porcine Plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 15;1076:54-60.

[2]. Rongjin Sun, et al. CYP3A4/5 Mediates the Metabolic Detoxification of Humantenmine, a Highly Toxic Alkaloid From Gelsemium Elegans Benth. J Appl Toxicol. 2019 Sep;39(9):1283-1292.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
463.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₂N₂O₃

[ Molecular Weight ]:
326.390

[ Flash Point ]:
234.2±31.5 °C

[ Exact Mass ]:
326.163055

[ PSA ]:
51.13000

[ LogP ]:
3.68

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.712

Safety Information

[ Hazard Codes ]:
Xi