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Gomisin L1

Names

[ CAS No. ]:
82467-50-3

[ Name ]:
Gomisin L1

[Synonym ]:
Gomisin M1
Gomisin L1
Benzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-1-ol, 5,6,7,8-tetrahydro-2,3,13-trimethoxy-6,7-dimethyl-, (6S,7R)-
UNII:6HN2PJ55D7
(-)-Gomisin L1
(6S,7R)-2,3,13-Trimethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-1-ol
Schisanhenol B

Biological Activity

[Description]:

Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC50 of <0.65 μM[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1


[In Vitro]

Gomisin M1 ((±)-Gomisin M1) (4 days) 具有抗 HIV-1 活性，在 H9 T 细胞中的 EC50 为 <0.65 μM，治疗指数 (TI) 为 >68[1]。

[References]

[1]. Chen M, et al. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. J Nat Prod. 2006 Dec;69(12):1697-701.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
568.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H26O6

[ Molecular Weight ]:
386.438

[ Flash Point ]:
297.7±30.1 °C

[ Exact Mass ]:
386.172943

[ PSA ]:
66.38000

[ LogP ]:
5.93

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.564

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds