2',5,6',7-Tetrahydroxyflavone

Names

[ CAS No. ]:
82475-00-1

[ Name ]:
2',5,6',7-Tetrahydroxyflavone

[Synonym ]:
4H-1-Benzopyran-4-one,2-(2,6-dihydroxyphenyl)-5,7-dihydroxy
5,7,2',6'-Tetrahydroxyflavone

Biological Activity

[Description]:

5,7,2',6'-Tetrahydroxyflavone is a natural flavonoid that inhibits hepatic testosterone 6β-hydroxylation (CYP3A4) activity with an IC50 of 7.8 μM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Metabolic Disease

[Target]

CYP3A4:7.8 μM (IC50)


[References]

[1]. Ji-Yeon Kim, et al. Effects of flavonoids isolated from Scutellariae radix on cytochrome P-450 activities in human liver microsomes. J Toxicol Environ Health A. 2002 Mar;65(5-6):373-81.  

Chemical & Physical Properties

[ Density]:
1.654g/cm3

[ Boiling Point ]:
589ºC at 760 mmHg

[ Molecular Formula ]:
C15H10O6

[ Molecular Weight ]:
286.23600

[ Flash Point ]:
228.9ºC

[ Exact Mass ]:
286.04800

[ PSA ]:
111.13000

[ LogP ]:
2.28240

[ Index of Refraction ]:
1.767

Related Compounds