Verubulin

Names

[ Name ]:
Verubulin

[Synonym ]:
Verubulin
4-Quinazolinamine, N-(4-methoxyphenyl)-N,2-dimethyl-
N-(4-Methoxyphenyl)-N,2-dimethyl-4-quinazolinamine
N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine

Biological Activity

[Description]:

Verubulin (MPC-6827) is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities, and acts as a promising candidate for the treatment of multiple cancer types[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

Microtubule[1]

[References]

[1]. Kasibhatla S, et al. MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps. Cancer Res. 2007 Jun 15;67(12):5865-71.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
398.7±38.0 °C at 760 mmHg

[ Melting Point ]:
86-90 °C

[ Molecular Formula ]:
C₁₇H₁₇N₃O

[ Molecular Weight ]:
279.336

[ Flash Point ]:
194.9±26.8 °C

[ Exact Mass ]:
279.137177

[ PSA ]:
38.25000

[ LogP ]:
2.02

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.652

[ Storage condition ]:
-20°C

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%