6-Aminophenanthridine

Names

[ CAS No. ]:
832-68-8

[ Name ]:
6-Aminophenanthridine

[Synonym ]:
6-Aminophenanthridine
Phenanthridin-6-ylamin
6-Phenanthridinamine
6-Amino-phenanthridin
phenanthridine-6-amine
Phenanthridine,6-amino
phenanthridin-6-ylamine
6-Phenanthridinamine (9CI)
9-Amino-phenanthridin
2-Aminobenzo(c)quinoline

Biological Activity

[Description]:

6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR). 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Pang Y, et al. The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition. J Biol Chem. 2013;288(26):19081-19089.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
406.4±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₀N₂

[ Molecular Weight ]:
194.232

[ Flash Point ]:
228.6±9.0 °C

[ Exact Mass ]:
194.084396

[ PSA ]:
39.64000

[ LogP ]:
2.96

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.780

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H319

[ Precautionary Statements ]:
P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII