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Regorafenib N-Oxide(M2)

Names

[ CAS No. ]:
835621-11-9

[ Name ]:
Regorafenib N-Oxide(M2)

[Synonym ]:
Regorafenib N-oxide (M2 Metabolite)
Regorafenib N-Oxide(M2)

Biological Activity

[Description]:

Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[References]

[1]. Allard M, et al. Simultaneous analysis of regorafenib and sorafenib and three of their metabolites in human plasma using LC-MS/MS. J Pharm Biomed Anal. 2017 Aug 5;142:42-48.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Molecular Formula ]:
C21H15ClF4N4O4

[ Molecular Weight ]:
498.81500

[ Exact Mass ]:
498.07200

[ PSA ]:
104.92000

[ LogP ]:
6.25920

Related Compounds