7-Chloro-4-(piperazin-1-yl)quinoline

Names

[ CAS No. ]:
837-52-5

[ Name ]:
7-Chloro-4-(piperazin-1-yl)quinoline

[Synonym ]:
7-chloro-4-piperazin-1-ylquinoline

Biological Activity

[Description]:

7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in medicinal chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor and also inhibits the serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone exhibits antimalarial activity on D10 and K1 strains of P. falciparum with IC50s of 1.18 μM and 0.97 μM, respectively[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[References]

[1]. Aida M Abd El-Sattar El-Azzouny, et al. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug Dev Res. 2020 Nov;81(7):786-802.

Chemical & Physical Properties

[ Density]:
1.257 g/cm3

[ Boiling Point ]:
433.5ºC at 760 mmHg

[ Melting Point ]:
113-116ºC

[ Molecular Formula ]:
C₁₃H₁₄ClN₃

[ Molecular Weight ]:
247.72300

[ Flash Point ]:
216ºC

[ Exact Mass ]:
247.08800

[ PSA ]:
28.16000

[ LogP ]:
2.69160

[ Index of Refraction ]:
1.636

[ Storage condition ]:
2-8°C

MSDS

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Safety Information

[ Hazard Codes ]:
C: Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S22-S26-S36/37/39-S45

[ HS Code ]:
2933990090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%