Ym-244769

Names

[ Name ]:
Ym-244769

Biological Activity

[Description]:

YM-244769 is a potent NCX (Na+/Ca2+ exchange) inhibitor that preferentially inhibits NCX3, with an IC50 of 18 nM. YM-244769 efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

IC50: 18 nM (NCX3)[1]

[In Vitro]

YM-244769 preferentially inhibits intracellular Na+-dependent 45Ca2+ uptake via NCX3; the inhibition is 3.8- to 5.3-fold greater than for the uptake via NCX1 or NCX2[1].

[References]

[1]. Iwamoto T, Kita S. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol Pharmacol. 2006 Dec;70(6):2075-83.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₂FN₃O₃

[ Molecular Weight ]:
443.47

Ym-244769

Names

Biological Activity

Chemical & Physical Properties

Related Compounds