ZK93423

Names

[ CAS No. ]:
83910-44-5

[ Name ]:
ZK93423

Biological Activity

[Description]:

ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> GABA Receptor

[In Vivo]

ZK 93423（0.3-3 mg/kg，i.p.）在 B6C3F 1 品系的雄性小鼠中以 3mg/kg 的剂量引起体温过低[1]。

[References]

[1]. A H Tang, et al. Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice. Eur J Pharmacol. 1993 May 12;236(1):1-5

Chemical & Physical Properties

[ Density]:
1.269g/cm3

[ Boiling Point ]:
619.1ºC at 760 mmHg

[ Molecular Formula ]:
C₂₃H₂₂N₂O₄

[ Molecular Weight ]:
390.43200

[ Flash Point ]:
328.2ºC

[ Exact Mass ]:
390.15800

[ PSA ]:
73.44000

[ LogP ]:
4.61820

[ Index of Refraction ]:
1.658

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%