[Tyr0] Corticotropin Releasing Factor, ovine

Names

[ Name ]:
[Tyr0] Corticotropin Releasing Factor, ovine

[Synonym ]:
H-Tyr-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2

Biological Activity

[Description]:

[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin[1][2].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Others

[In Vitro]

[Tyr0] Corticotropin Releasing Factor, ovine has a strong binding effect with plasma protein[1].

[In Vivo]

[Tyr0] Corticotropin Releasing Factor, ovine (328 μCi/μg; 198 pg/min or 225 pg/min; continuous infusions intravenous; single dose lasting 5-7 hr) shows a long plasma half-life and low metabolic clearance rate in male cynomolgus monkeys[1]. Animal Model: Young adult male cynomolgus monkeys (4.0-6.9 kg)[1] Dosage: 10 mL/h for 198 pg/min or 225 pg/min Administration: Continuous infusions intravenous; collected every 60 min during 5-7 hr Result: Showed a longer plasma half-life than for all other known hypothalamic peptides and its metabolic clearance rate was relatively low and considerably less all other known hypothalamic peptides or adreno-cortico-tropic-hormone (ACTH).

[References]

[1]. Schulte HM, et al. Metabolic clearance rate and plasma half-life of radioiodinated corticotropin releasing factor in a primate. J Clin Endocrinol Metab. 1982 Nov;55(5):1023-5.

[2]. Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁₄H₃₄₈N₆₀O₆₅S₁

[ Molecular Weight ]:
4833.48

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Actions of CRF and its analogs.

Curr. Med. Chem. 6 , 1035-1053, (1999)

Corticotropin-releasing factor (CRF), urocortin, sauvagine and urotensin I form the CRF family. These peptides bind with different affinities to two subtypes of CRF receptor (CRFR), CRFR1 and CRFR2. T...

Corticotropin-releasing factor (CRF) and endocrine responses to stress: CRF receptors, binding protein, and related peptides.

Proc. Soc. Exp. Biol. Med. 215(1) , 1-10, (1997)

Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide, which is recognized as a critical mediator of complimentary, stress-related endocrine, autonomic, and behavioral responses in mamm...

Binding of [125I]Tyr-corticotropin-releasing factor to rabbit aorta is reduced by removal of the endothelium.

Eur. J. Pharmacol. 135 , 111-112, (1987)